This product is a click-reactive phospholipid featuring a hydrophobic DSPE lipid anchor and terminal alkyne functionality, while the alkyne group supports copper-catalyzed azide–alkyne cycloaddition (CuAAC) with compatible azide-functionalized molecules.
Key Features and Benefits
- Alkyne-Functionalized Phospholipid: DSPE-Alkyne provides terminal alkyne functionality for click chemistry and conjugation.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that support incorporation into compatible lipid membranes and assemblies.
- Alkyne Functionality: The terminal alkyne provides a reactive site for coupling with compatible azide-containing molecules.
- CuAAC Click Chemistry: The alkyne group specifically supports copper-catalyzed azide–alkyne cycloaddition under suitable reaction conditions.
- Stable Triazole Formation: CuAAC between terminal alkynes and azides produces stable covalent triazole linkages.
- Amphiphilic Character: The DSPE structure supports incorporation into compatible liposomes, lipid nanoparticles, and membrane systems.
- Surface Functionalization: DSPE-Alkyne specifically provides click-reactive functionality at lipid interfaces for subsequent modification.
- Functional Lipid Platform: The combination of a DSPE anchor and alkyne specifically supports diverse click chemistry and biomaterial applications.
Applications
- Click Chemistry: DSPE-Alkyne (Alkyne-Functionalized DSPE) supports CuAAC reactions with compatible azide-functionalized molecules.
- Bioconjugation: Enables covalent attachment of azide-containing peptides, proteins, probes, and other biomolecules.
- Ligand Conjugation: Supports attachment of azide-functionalized ligands through stable triazole linkages.
- Liposome Functionalization: Enables incorporation of alkyne-functionalized phospholipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides a click-reactive lipid component for experimental lipid nanoparticle formulations.
- Nanoparticle Functionalization: Supports azide-alkyne conjugation on compatible lipid-containing nanoparticles.
- Surface Modification: Provides terminal alkyne functionality for modification of compatible lipid and material interfaces.
- Biomaterial Research: Supports development of click-functionalized lipid conjugates, assemblies, nanoparticles, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
This product combines a hydrophobic DSPE lipid anchor with terminal alkyne functionality and specifically provides a versatile platform for CuAAC click chemistry, bioconjugation, lipid functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
