DSPE-Azide

DSPE-Azide (DSPE-N3) is an azide-functionalized phospholipid derivative composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and a terminal azide group. The azide moiety enables efficient bioorthogonal click chemistry conjugation with alkyne- and DBCO-modified molecules via both CuAAC and copper-free SPAAC reactions. DSPE-N3 readily forms stable lipid bilayers in aqueous environments, making it a key material for liposome preparation, lipid nanoparticle functionalization, membrane surface modification, targeted drug delivery, molecular imaging, and nanomedicine research.

Key Features:

• Azide-functionalized phospholipid enabling versatile click chemistry conjugation with alkynes and DBCO derivatives.
• Compatible with both copper-catalyzed (CuAAC) and copper-free (SPAAC) bioorthogonal reaction systems.
• Excellent lipid bilayer-forming property for stable liposome and nanoparticle construction.
• High biocompatibility suitable for in vitro and in vivo biomedical applications.
• Enables efficient surface functionalization of lipid-based drug delivery systems.

Applications:

• Liposome and lipid nanoparticle engineering for targeted drug delivery.
• Surface modification of biological membranes and nanocarriers.
• Bioorthogonal labeling and bioconjugation in molecular imaging studies.
• Development of targeted nanomedicines and controlled-release delivery systems.
• Functional probe preparation and biomembrane research in pharmaceutical development.