DSPE-Azide (DSPE-N3) provides an azide-functionalized phospholipid for click chemistry, bioconjugation, and lipid-based material research that specifically combines a hydrophobic DSPE lipid anchor with a terminal azide (–N₃) for CuAAC and SPAAC reactions.
Key Features and Benefits
- Azide-Functionalized Phospholipid: DSPE-Azide combines a phospholipid structure with terminal azide functionality for selective conjugation.
- DSPE Lipid Anchor: The DSPE component contains two saturated C18 stearoyl chains that provide a hydrophobic lipid anchor.
- Azide Functionality: The terminal –N₃ group provides a bioorthogonal reactive site for click chemistry and molecular modification.
- CuAAC Click Chemistry: The azide reacts with terminal alkynes specifically through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: The azide reacts with strained cyclooctynes such as DBCO without requiring a copper catalyst.
- Stable Triazole Formation: Azide-alkyne click reactions form stable triazole linkages specifically with compatible reaction partners.
- Amphiphilic Character: The hydrophobic lipid chains and polar headgroup specifically support incorporation into compatible lipid assemblies.
- Surface Functionalization: Terminal azide functionality enables click-based modification of lipid membranes and nanoparticle surfaces.
Applications
- Click Chemistry: DSPE-Azide (DSPE-N3) provides terminal azide functionality for CuAAC and SPAAC reactions.
- Bioconjugation: Supports attachment of compatible alkyne- and cyclooctyne-functionalized biomolecules, probes, and ligands.
- Ligand Conjugation: Enables click-based attachment of targeting ligands and other functional molecules.
- Liposome Functionalization: Supports incorporation of click-reactive functionality into compatible liposomal systems.
- LNP Research: Provides an azide-functionalized lipid for lipid nanoparticle formulation and surface modification research.
- Nanoparticle Functionalization: Supports click-based modification of compatible nanoparticle surfaces.
- Surface Modification: Enables introduction of azide functionality into lipid-coated surfaces and material interfaces.
- Biomaterial Research: Supports development of functional lipid assemblies, conjugates, nanoparticles, and biomaterials.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-Azide (DSPE-N3) combines a DSPE lipid anchor with click-reactive azide functionality that specifically supports CuAAC, SPAAC, bioconjugation, liposome functionalization, lipid nanoparticle research, and surface modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
