Azide-PEG2-Azide provides a compact homobifunctional PEG linker with terminal azide groups at both ends. Its two azide groups support especially efficient click chemistry, enabling conjugation, crosslinking, and molecular assembly in chemical and biomaterial research.
Key Features and Benefits
- Homobifunctional PEG Linker: Contains reactive azide groups at both ends of a short PEG spacer.
- PEG2 Spacer: The compact PEG2 chain specifically provides hydrophilicity and controlled spacing between reactive groups.
- Dual Azide Functionality: Two terminal azide groups specifically enable bifunctional conjugation and molecular linking.
- CuAAC Click Chemistry: The azide groups specifically react with terminal alkynes through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: The azides react with strained cyclooctynes such as DBCO without requiring a copper catalyst.
- Stable Triazole Formation: Click reactions form stable triazole linkages between Azide-PEG2-Azide and compatible reaction partners.
- Compact Linker Design: The short PEG2 spacer minimizes linker length while maintaining useful hydrophilic character.
- Versatile Conjugation Platform: The bifunctional structure supports molecular assembly, crosslinking, and surface functionalization.
Applications
- Click Chemistry: Azide-PEG2-Azide supports both CuAAC and SPAAC conjugation strategies.
- Bioconjugation: The dual azide groups enable linking with compatible alkyne- or cyclooctyne-functionalized molecules.
- Crosslinking: Two reactive termini allow Azide-PEG2-Azide to connect compatible molecules through click reactions.
- Molecular Assembly: Supports construction of functional conjugates and multicomponent molecular systems.
- Surface Modification: Enables click-based functionalization of appropriately modified surfaces and materials.
- Polymer Functionalization: Supports incorporation of azide functionality into compatible polymer systems.
- Linker Chemistry: Provides a compact PEG2 spacer specifically for synthetic and conjugation workflows.
- Biomaterial Research: Supports development of functional materials, conjugates, and chemically modified biomaterials.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Use appropriate conditions for azide-containing research reagents.
This product combines a compact PEG2 spacer with two terminal azide groups for versatile click chemistry and specifically supports CuAAC, SPAAC, crosslinking, bioconjugation, molecular assembly, and material functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
