DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) CAS:816-94-4 is a phosphatidylcholine with an 18-carbon alkyl chain. It has a melting temperature of about 54°C and a cylindrical geometry that allows DSPC molecules to form a lamellar phase, thereby stabilizing the structure of lipid nanoparticles. Can be combined with other members of the phosphatidylcholine family to create hybrid bilayer systems. DSPC has been used in mRNA-1273 and BNT162b2 COVID-19 vaccines.
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