DSG‑PEG, MW 1000

Core Structure & Properties

• Amphiphilic design:
  • Hydrophobic domain: Two saturated C18:0 stearoyl chains on a glycerol backbone (DSG), acting as a stable membrane anchor.
  • Hydrophilic domain: PEG‑1000 chain (typically methoxy‑terminated, mPEG‑DSG) providing excellent water solubility and strong steric stabilization.
• Physical form: White to off‑white solid/powder.
• Solubility: Soluble in DMSO, DCM, DMF, ethanol, chloroform, THF; readily dispersible in aqueous solutions.
• Purity: Typically ≥90% (analytical grade).
• Storage: −20 °C, desiccated; stable under neutral conditions.

Key Functions

1. Lipid nanoparticle (LNP) / liposome PEGylationBroadPharm
   • Inserts stably into lipid bilayers via the DSG anchor; the longer PEG‑1000 chain forms a robust hydration layer on the particle surface.
   • Significantly reduces non‑specific protein adsorption and immune recognition, greatly prolonging in vivo circulation time.
   • Enhances colloidal stability and prevents aggregation during storage and administration.
2. Controlled release & formulation tuning
   • PEG‑1000 provides a balanced hydrophilic‑lipophilic profile, ideal for sustained‑release delivery systems.
   • Highly compatible with cationic lipids for efficient nucleic acid (mRNA, siRNA, plasmid DNA) delivery.
3. Surface functionalization
   • Serves as a versatile building block for targeted carriers; end‑functionalized variants (e.g., DSG‑PEG1000‑NH₂, ‐COOH, ‐N₃, ‐Biotin) enable conjugation to antibodies, peptides, ligands, or fluorescent probesMedChemExp….

Main Applications

• Drug delivery: Formulation of LNPs, liposomes, and micelles for small‑molecule drugs, proteins, and nucleic acids.
• Gene therapy: Non‑viral vector stabilization and enhanced transfection efficiency.
• Biomedical research: Surface modification of nanocarriers, in vitro/in vivo delivery studies, and targeted imaging.