DOPE-PEG-Maleimide, MW 3.4K is a thiol-reactive phospholipid-PEG conjugate containing a hydrophobic DOPE lipid anchor and hydrophilic 3.4K PEG spacer, while its terminal maleimide group supports selective thiol conjugation, bioconjugation, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DOPE-PEG-Maleimide combines a hydrophobic phospholipid anchor with a hydrophilic PEG chain.
- PEG MW 3.4K: The 3.4K PEG spacer provides hydrophilic character and separates the terminal maleimide from the lipid anchor.
- DOPE Lipid Anchor: Dioleoyl phosphatidylethanolamine specifically provides two unsaturated lipid chains for incorporation into lipid membranes and assemblies.
- Maleimide Functionality: The terminal maleimide specifically provides a reactive site for conjugation with thiol-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with sulfhydryl groups under suitable conditions.
- Stable Conjugation: Maleimide-thiol coupling specifically forms a stable thioether linkage for functional conjugate development.
- PEG Spacer: The PEG chain provides spatial separation between the DOPE anchor and reactive maleimide group.
- Functional Lipid Platform: DOPE, PEG, and maleimide functionality specifically support modification of lipid and nanomaterial systems.
Applications
- Thiol Conjugation: Researchers use DOPE-PEG-Maleimide, MW 3.4K to conjugate compatible thiol-containing molecules.
- Bioconjugation: Supports coupling with cysteine-containing peptides, proteins, and other sulfhydryl-functionalized molecules.
- Lipid Nanoparticle Research: Enables surface functionalization of lipid-based nanoparticles with thiol-containing ligands.
- Liposome Research: Supports incorporation of PEG and maleimide functionality into liposomes and other phospholipid assemblies.
- Ligand Conjugation: The terminal maleimide enables attachment of compatible thiol-functionalized ligands.
- Nanoparticle Functionalization: Supports thiol-mediated modification of compatible nanoparticles and nanomaterials.
- Surface Modification: Provides a thiol-reactive PEG linker for functional surface engineering.
- Biomaterial Research: Supports development of functional lipid-PEG materials and thiol-reactive conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis. Allow the material to reach room temperature before opening.
DOPE-PEG-Maleimide, MW 3.4K combines a DOPE lipid anchor, hydrophilic PEG spacer, and thiol-reactive maleimide group and specifically supports bioconjugation, ligand attachment, lipid nanoparticle modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
