DOPE-Maleimide is a maleimide-functionalized phospholipid combining a hydrophobic DOPE lipid structure with reactive maleimide functionality, while its maleimide group supports thiol-selective conjugation for bioconjugation, lipid functionalization, nanoparticle modification, and biomaterial research.
Key Features and Benefits
- Maleimide-Functionalized Phospholipid: DOPE-Maleimide combines the lipid properties of DOPE with thiol-reactive maleimide functionality.
- DOPE Lipid Structure: DOPE contains two unsaturated C18 oleoyl chains that specifically support incorporation into lipid membranes and assemblies.
- Maleimide Functionality: The maleimide group specifically provides a reactive site for conjugation with sulfhydryl-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with thiol groups under suitable conditions.
- Stable Conjugation: Maleimide-thiol coupling specifically forms a stable thioether linkage for functional conjugate development.
- Lipid Membrane Incorporation: The hydrophobic oleoyl chains support incorporation into compatible lipid membranes and assemblies.
- Bioconjugation Capability: Maleimide chemistry enables attachment of thiolated peptides, proteins, ligands, and other functional molecules.
- Functional Lipid Platform: DOPE and maleimide functionality provide an especially versatile platform for thiol-reactive lipid research.
Applications
- Thiol Conjugation: DOPE-Maleimide supports conjugation with thiol- and cysteine-containing molecules.
- Bioconjugation: The maleimide functionality enables attachment of compatible peptides, proteins, ligands, and other thiolated molecules.
- Lipid Nanoparticle Research: Supports incorporation of thiol-reactive lipid functionality into experimental lipid nanoparticle systems.
- Liposome Research: Enables preparation and functionalization of maleimide-containing liposomes and related lipid assemblies.
- Ligand Conjugation: Supports attachment of thiol-containing ligands through maleimide-thiol chemistry.
- Nanoparticle Functionalization: Provides maleimide functionality for modification of compatible lipid-containing nanoparticles.
- Membrane Research: Supports studies involving functionalized phospholipid membranes and lipid assemblies.
- Biomaterial Research: Enables development of thiol-reactive lipid materials and functional biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis. Allow the material to reach room temperature before opening.
This product combines an unsaturated DOPE lipid structure with thiol-reactive maleimide functionality and specifically supports thiol conjugation, lipid functionalization, bioconjugation, nanoparticle modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
