DMPE-PEG-COOH, MW 1K is a carboxyl-functionalized phospholipid-PEG conjugate containing a hydrophobic DMPE lipid anchor and hydrophilic 1K PEG spacer, while its terminal carboxyl group supports bioconjugation, ligand attachment, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DMPE-PEG-COOH combines a hydrophobic phospholipid anchor with a hydrophilic PEG chain.
- PEG MW 1K: The 1K PEG spacer provides hydrophilic character and separates the terminal carboxyl group from the lipid anchor.
- DMPE Lipid Anchor: Dimyristoyl phosphatidylethanolamine provides two saturated C14 lipid chains for incorporation into lipid membranes and assemblies.
- Carboxyl Functionality: The terminal COOH group provides a reactive site for conjugation and further chemical modification.
- Amine Coupling: The carboxyl group specifically supports coupling with primary amines after activation with suitable coupling reagents.
- EDC/NHS Chemistry: Carboxyl activation with EDC/NHS can specifically enable amide bond formation with compatible amine-containing molecules.
- PEG Spacer: The PEG chain specifically provides spatial separation between the DMPE anchor and terminal carboxyl functionality.
- Functional Lipid Platform: DMPE, PEG, and COOH functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Bioconjugation: Researchers use DMPE-PEG-COOH, MW 1K to conjugate compatible amine-containing molecules.
- Ligand Conjugation: The terminal carboxyl group supports attachment of amine-containing peptides, proteins, ligands, and other molecules.
- Lipid Nanoparticle Research: Enables introduction of PEG and carboxyl functionality into lipid-based nanoparticle systems.
- Liposome Research: Supports functionalization of liposomes and other phospholipid assemblies.
- Nanoparticle Functionalization: Provides a terminal COOH group for modification of compatible nanoparticle systems.
- Surface Modification: Supports carboxyl-functional PEG presentation on compatible lipid and material surfaces.
- Drug Delivery Research: Provides a functional phospholipid-PEG component for experimental delivery-system development.
- Biomaterial Research: Supports development of carboxyl-functionalized lipid-PEG materials and conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DMPE-PEG-COOH, MW 1K combines a DMPE lipid anchor, hydrophilic PEG spacer, and terminal carboxyl group and specifically supports amine coupling, bioconjugation, lipid nanoparticle modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
