DMPE-PEG-Amine, MW 5K is an amine-functionalized phospholipid-PEG conjugate containing a hydrophobic DMPE lipid anchor and hydrophilic 5K PEG spacer, while its terminal primary amine supports bioconjugation, ligand attachment, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DMPE-PEG-Amine combines a hydrophobic phospholipid anchor with a hydrophilic PEG chain.
- PEG MW 5K: The 5K PEG spacer provides hydrophilic character and separates the terminal amine from the lipid anchor.
- DMPE Lipid Anchor: Dimyristoyl phosphatidylethanolamine specifically provides two saturated C14 lipid chains for incorporation into lipid membranes and assemblies.
- Primary Amine Functionality: The terminal amine provides a reactive site specifically for conjugation and further chemical modification.
- Amine-Reactive Coupling: The primary amine reacts with activated carboxyl groups, NHS esters, and other compatible amine-reactive functionalities.
- Stable Amide Formation: Coupling with activated carboxyl groups can specifically form stable amide linkages for functional conjugate development.
- PEG Spacer: The PEG chain provides spatial separation between the DMPE anchor and terminal amine group.
- Functional Lipid Platform: DMPE, PEG, and amine functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Bioconjugation: Researchers use DMPE-PEG-Amine, MW 5K to conjugate compatible amine-reactive molecules.
- Ligand Conjugation: The terminal amine supports attachment of activated ligands, peptides, proteins, and other functional molecules.
- Lipid Nanoparticle Research: Enables introduction of PEG and amine functionality into lipid-based nanoparticle systems.
- Liposome Research: Supports functionalization of liposomes and other phospholipid assemblies.
- Nanoparticle Functionalization: Provides a terminal primary amine for modification of compatible nanoparticle systems.
- Surface Modification: Supports amine-functional PEG presentation on compatible lipid and material surfaces.
- Drug Delivery Research: Provides a functional phospholipid-PEG component for experimental delivery-system development.
- Biomaterial Research: Supports development of amine-functionalized lipid-PEG materials and conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DMPE-PEG-Amine, MW 5K combines a DMPE lipid anchor, hydrophilic PEG spacer, and reactive terminal primary amine and specifically supports bioconjugation, ligand attachment, lipid nanoparticle modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
