Alkyne-Polysarcosine-40 is an alkyne-functionalized hydrophilic polypeptoid with approximately 40 sarcosine repeat units. It combines a compact polysarcosine chain with terminal alkyne functionality specifically for click chemistry, bioconjugation, surface modification, and biomaterial research.
Key Features and Benefits
- Alkyne-Functionalized Polysarcosine: Combines a hydrophilic polysarcosine backbone with a terminal alkyne group for selective functionalization.
- 40 Repeat Units: Provides approximately 40 sarcosine units for applications requiring a compact hydrophilic polymer chain.
- Alkyne Functionality: The terminal alkyne provides a reactive site specifically for coupling with compatible azide-containing molecules.
- Click Chemistry Platform: Supports CuAAC reactions between the terminal alkyne and azide-functionalized molecules.
- High Hydrophilicity: The polysarcosine backbone provides strong hydrophilic character and specifically supports aqueous compatibility.
- Low Nonspecific Interactions: Polysarcosine can help reduce nonspecific protein interactions in suitable polymer and surface systems.
- PEG Alternative: Provides a non-PEG hydrophilic platform specifically for functional polymer design, conjugation, and surface engineering.
- Versatile Functionalization: Combines click-reactive functionality with a hydrophilic polymer chain for advanced material development.
Applications
- Click Chemistry: Supports CuAAC coupling with compatible azide-functionalized molecules.
- Bioconjugation: Enables attachment of compatible azide-functionalized peptides, proteins, ligands, and other molecules.
- Polymer Functionalization: Supports incorporation into block copolymers, polymer conjugates, and other functional architectures.
- Nanoparticle Functionalization: Enables click-mediated modification of compatible nanoparticles and polymeric systems.
- Surface Modification: Supports attachment of polysarcosine chains to suitably azide-functionalized surfaces.
- Drug Delivery: Supports development of functional hydrophilic polymer systems for drug-delivery research.
- Low-Fouling Materials: Supports development of hydrophilic materials designed to reduce nonspecific interactions.
- Biomaterial Research: Supports development of polymer conjugates, functional surfaces, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
Alkyne-Polysarcosine-40 combines a compact hydrophilic polysarcosine chain with terminal alkyne functionality and specifically supports click chemistry, bioconjugation, surface modification, nanoparticle functionalization, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
