DMPE-PEG-Azide, MW 5K is an azide-functionalized phospholipid-PEG conjugate containing a hydrophobic DMPE lipid anchor and hydrophilic 5K PEG spacer. Its terminal azide group supports click chemistry, bioconjugation, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DMPE-PEG-Azide combines a hydrophobic phospholipid anchor with a hydrophilic PEG chain.
- PEG MW 5K: The 5K PEG spacer provides hydrophilic character and separates the terminal azide from the lipid anchor.
- DMPE Lipid Anchor: Dimyristoyl phosphatidylethanolamine specifically provides two saturated C14 lipid chains for incorporation into lipid membranes and assemblies.
- Azide Functionality: The terminal azide specifically provides a bioorthogonal reactive group for click chemistry and functional conjugation.
- CuAAC Click Chemistry: The azide reacts with terminal alkynes through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: The azide also reacts with strained cyclooctynes, such as DBCO, without requiring a copper catalyst.
- PEG Spacer: The PEG chain provides spatial separation between the DMPE anchor and reactive azide group.
- Functional Lipid Platform: DMPE, PEG, and azide functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Click Chemistry: Researchers use DMPE-PEG-Azide, MW 5K for CuAAC and SPAAC conjugation reactions.
- Bioconjugation: Supports attachment of compatible alkyne- and cyclooctyne-functionalized peptides, proteins, ligands, and other molecules.
- Lipid Nanoparticle Research: Enables introduction of PEG and azide functionality into lipid-based nanoparticle systems.
- Liposome Research: Supports functionalization of liposomes and other phospholipid assemblies.
- Ligand Conjugation: The terminal azide enables click-based attachment of compatible functionalized ligands.
- Nanoparticle Functionalization: Supports click-mediated modification of compatible nanoparticles and nanomaterials.
- Surface Modification: Provides an azide-functional PEG linker for functional surface engineering.
- Biomaterial Research: Supports development of clickable lipid-PEG conjugates and functional biomaterial systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DMPE-PEG-Azide, MW 5K combines a DMPE lipid anchor, hydrophilic PEG spacer, and click-reactive terminal azide and specifically supports CuAAC and SPAAC chemistry, bioconjugation, lipid nanoparticle modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
