DMPE‑PEG‑Azide (MW 1 000)
Full Name: 1,2‑Dimyristoyl‑sn‑glycero‑3‑phosphoethanolamine‑N‑(polyethylene glycol)‑azide, MW 1 000
1. Basic Properties
- Molecular Weight: PEG segment ~1 000 Da; total conjugate ~1 700–1 800 Da
- Structure: Amphiphilic block copolymer
- Hydrophobic tail: DMPE (1,2‑dimyristoyl‑sn‑glycero‑3‑phosphoethanolamine)
- Hydrophilic spacer: linear PEG (MW 1 000)
- Reactive end: azide (‑N₃) group
- Appearance: Solid or viscous liquid
- Solubility: Good solubility in water and most organic solvents (DCM, DMF, DMSO, THF)
- Purity: Typically ≥ 95% (HPLC/GPC)
- Storage: Store at ≤ −4 °C, dry, avoid repeated freeze‑thaw cycles
2. Key Chemical Reactivity
The terminal azide group enables click chemistry conjugation under mild conditions:
- CuAAC: Copper‑catalyzed azide‑alkyne cycloaddition with alkynes to form stable triazoles
- SPAAC: Strain‑promoted azide‑alkyne cycloaddition with DBCO/BCN groups (metal‑free)
3. Main Applications
- Liposome & Nanoparticle Engineering:
- Form stealth liposomes with prolonged circulation time and improved stability
- Surface functionalization of lipid‑based nanoparticles for targeted delivery
- Biomedical Research:
- Drug delivery (chemotherapeutics, siRNA) via EPR effect
- Cell labeling, imaging, and biosensor development
- Targeted therapy and immunotherapy conjugation
- Materials Science:
- Surface modification of biomaterials
- 3D bioprinting and tissue engineering
4. Typical Use Cases
- Preparation of long‑circulating liposomes
- Conjugation to alkyne‑labeled proteins, peptides, or fluorophores
- Surface functionalization of lipid nanoparticles for targeted delivery
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
