DMPE-PEG-Amine 1K

Key Properties

• An amphiphilic phospholipid-PEG conjugate composed of a hydrophobic DMPE lipid anchor, a hydrophilic PEG 1000 spacer, and a reactive terminal primary amine (-NH₂) group.
• Neutral at physiological pH and can stably insert into lipid bilayers to provide a stealth PEG layer.
• The amine group enables efficient conjugation with NHS esters, carboxyl groups, isothiocyanates, and epoxides under mild conditions to form stable amide bonds.
• Good biocompatibility, low toxicity, and high stability in aqueous solutions.
• Soluble in chloroform, methanol, ethanol, and DMSO; dispersible in aqueous buffers.
• Typically appears as a white to off-white waxy solid or powder.
• Storage: −20 °C, desiccated, protected from light and moisture.

Applications

• Used as a reactive PEGylated lipid for surface modification of liposomes, lipid nanoparticles (LNPs), micelles, and exosomes.
• Enables covalent coupling with NHS ester–modified targeting ligands, antibodies, peptides, aptamers, fluorescent dyes, and imaging probes.
• Improves colloidal stability, reduces aggregation, and prolongs in vivo circulation time of nanocarriers.
• Widely used in drug delivery systems for mRNA, siRNA, DNA, proteins, and small-molecule drugs.
• Applied in targeted therapeutics, vaccine development, and biological imaging.
• Serves as a versatile building block for functionalization of lipid-based nanomedicines and biomaterials.