DMPE-PEG-Mal, MW 5K is a maleimide-functionalized phospholipid-PEG conjugate containing a hydrophobic DMPE lipid anchor and hydrophilic 5K PEG spacer, while its terminal maleimide provides selective reactivity toward thiol-containing molecules for bioconjugation and lipid functionalization.
Key Features and Benefits
- Amphiphilic Structure: DMPE-PEG-Mal combines a hydrophobic phospholipid anchor with a hydrophilic PEG chain.
- PEG MW 5K: The 5K PEG spacer provides hydrophilic character and separates the reactive maleimide from the lipid anchor.
- DMPE Lipid Anchor: Dimyristoyl phosphatidylethanolamine specifically provides two saturated C14 lipid chains for incorporation into lipid membranes and assemblies.
- Maleimide Functionality: The terminal maleimide specifically provides a reactive site for conjugation with sulfhydryl-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with thiol groups under suitable conditions.
- Stable Conjugation: Maleimide-thiol coupling forms a stable thioether linkage specifically for functional conjugate development.
- PEG Spacer: The PEG chain provides spatial separation between the DMPE anchor and reactive maleimide group.
- Functional Lipid Platform: DMPE, PEG, and maleimide functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Thiol Conjugation: DMPE-PEG-Mal, MW 5K supports conjugation with thiol- and cysteine-containing molecules.
- Bioconjugation: The terminal maleimide enables attachment of compatible peptides, proteins, ligands, and other thiolated molecules.
- Lipid Nanoparticle Research: Supports introduction of thiol-reactive PEG functionality into lipid-based nanoparticle systems.
- Liposome Research: Enables functionalization of liposomes and other phospholipid assemblies.
- Ligand Conjugation: Supports attachment of thiol-containing ligands through maleimide-thiol chemistry.
- Nanoparticle Functionalization: Provides a reactive maleimide group for modifying compatible nanoparticle systems.
- Surface Modification: Supports thiol-reactive PEG presentation on compatible lipid and material surfaces.
- Biomaterial Research: Enables development of maleimide-functionalized lipid-PEG materials and conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis. Allow the material to reach room temperature before opening.
DMPE-PEG-Mal, MW 5K combines a DMPE lipid anchor, hydrophilic PEG spacer, and thiol-reactive maleimide group and specifically supports bioconjugation, ligand attachment, lipid nanoparticle modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
