DMG-PEG-Azide, MW 2K is an azide-functionalized lipid-PEG conjugate containing a hydrophobic DMG lipid anchor and hydrophilic 2K PEG spacer, while its terminal azide (-N₃) supports click chemistry, bioconjugation, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DMG-PEG-Azide combines a hydrophobic lipid anchor with a hydrophilic PEG chain.
- PEG MW 2K: The 2K PEG spacer provides hydrophilic character and separates the terminal azide from the lipid anchor.
- DMG Lipid Anchor: Dimyristoyl glycerol provides two saturated C14 lipid chains that specifically support incorporation into lipid-based assemblies.
- Azide Functionality: The terminal azide (-N₃) provides a bioorthogonal reactive site for click chemistry and conjugation.
- CuAAC Click Chemistry: The azide reacts with terminal alkynes through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: The azide reacts with strained cyclooctynes, such as DBCO, without requiring a copper catalyst.
- PEG Spacer: The PEG chain specifically provides spatial separation between the DMG lipid anchor and terminal azide group.
- Functional Lipid Platform: DMG, PEG, and azide functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Click Chemistry: DMG-PEG-Azide, MW 2K supports CuAAC and SPAAC reactions with compatible alkyne-functionalized molecules.
- Bioconjugation: The terminal azide enables attachment of compatible ligands, peptides, proteins, and other functional molecules.
- Lipid Nanoparticle Research: Supports introduction of click-reactive PEG functionality into lipid-based nanoparticle systems.
- Liposome Research: Enables functionalization of liposomes and other lipid assemblies through azide-based conjugation.
- Ligand Conjugation: Supports attachment of alkyne- or cyclooctyne-functionalized ligands through click chemistry.
- Nanoparticle Functionalization: Provides a terminal azide for modification of compatible nanoparticle systems.
- Surface Modification: Supports click-reactive PEG presentation on compatible lipid and material surfaces.
- Biomaterial Research: Enables development of azide-functionalized lipid-PEG materials and conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DMG-PEG-Azide, MW 2K combines a hydrophobic DMG lipid anchor, hydrophilic PEG spacer, and click-reactive terminal azide and specifically supports CuAAC, SPAAC, lipid functionalization, bioconjugation, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.