DMG-PEG-Azide 2000

Key Properties

• A PEGylated reactive lipid consisting of a hydrophobic DMG (1,2-dimyristoyl-rac-glycerol) anchor, a PEG 2000 hydrophilic spacer, and a terminal azide (-N₃) functional group.
• Electrically neutral at physiological pH and shows high stability in lipid nanoparticle (LNP) formulations.
• Undergoes efficient bioorthogonal click chemistry with alkyne or DBCO-modified molecules via CuAAC or copper-free SPAAC under mild conditions.
• Provides strong stealth effect, reduces particle aggregation, and minimizes nonspecific protein adsorption.
• Excellent biocompatibility, low immunogenicity, and high formulation stability.
• Soluble in chloroform, methanol, and DMSO; compatible with standard LNP preparation processes.
• Usually a white to off-white waxy solid.
• Storage: −20 °C, desiccated, protected from light and moisture.

Applications

• Widely used as a functional PEG lipid for surface functionalization of mRNA/siRNA/DNA lipid nanoparticles (LNPs) and liposomes.
• Enables covalent conjugation with DBCO‑ or alkyne‑modified targeting ligands, antibodies, peptides, aptamers, and fluorescent probes.
• Improves colloidal stability and extends blood circulation time of nanocarriers.
• Used in targeted drug delivery, vaccine development, and in vivo molecular imaging.
• Serves as a key component for modular engineering of targeted LNP systems.
• Applied in biomembrane labeling and surface modification of biomaterials.