DMG-PEG-Amine 1000

Key Properties

• An amphiphilic PEGylated lipid consisting of a hydrophobic DMG domain, a hydrophilic PEG 1000 spacer, and a reactive terminal amine (-NH₂) group.
• Neutral amphiphile that stably inserts into lipid bilayers of LNPs and liposomes.
• The primary amine group readily reacts with NHS esters, carboxyl groups, and isothiocyanates to form stable amide or thiourea bonds.
• Provides excellent colloidal stability and reduces non-specific protein adsorption.
• Good biocompatibility, low toxicity, and high stability in aqueous formulations.
• Soluble in chloroform, methanol, and DMSO; compatible with standard lipid nanoparticle preparation.
• Usually a white to off-white waxy solid.
• Storage: −20 °C, desiccated, protected from light and moisture.

Applications

• Used as a reactive PEG lipid for surface functionalization of lipid nanoparticles (LNPs) and liposomes.
• Enables covalent conjugation with NHS-ester modified ligands, peptides, antibodies, dyes, and targeting molecules.
• Applied in delivery systems for mRNA, siRNA, DNA, and protein therapeutics.
• Improves particle stability and prolongs in vivo circulation time.
• Used in targeted drug delivery, vaccine development, and biological imaging.
• Serves as a versatile building block for surface modification of lipid-based nanomedicines.