DMG-PEG-Azide 1000

Key Properties

• A reactive PEGylated lipid composed of a hydrophobic DMG anchor, a hydrophilic PEG 1000 spacer, and a terminal azide (-N₃) group.
• Amphiphilic and electrically neutral at physiological pH, enabling stable integration into lipid bilayers of LNPs and liposomes.
• Undergoes highly efficient bioorthogonal click reactions with alkyne or DBCO-modified molecules, either via copper-catalyzed (CuAAC) or copper-free (SPAAC) coupling under mild conditions.
• Provides excellent colloidal stability and antifouling (stealth) effect to reduce non-specific interactions.
• Good biocompatibility, low toxicity, and suitable for in vivo delivery systems.
• Soluble in chloroform, methanol, and DMSO; dispersible in aqueous buffers.
• Typically a white to off-white waxy solid.
• Storage: −20 °C, desiccated, protected from light and moisture.

Applications

• Used as a functional PEG lipid for targeted surface modification of lipid nanoparticles (LNPs), liposomes, and micelles.
• Enables covalent conjugation with alkyne/DBCO-functionalized targeting ligands, antibodies, peptides, aptamers, and imaging probes.
• Applied in mRNA, siRNA, DNA, and gene-editing delivery systems to improve targeting efficiency.
• Enhances nanoparticle stability and prolongs blood circulation time.
• Used in the development of targeted therapeutics, theranostic nanocarriers, and vaccine delivery platforms.
• Serves as a versatile building block for modular functionalization of lipid-based nanomedicines.