DMG-PEG-Mal, MW 2K is a maleimide-functionalized lipid-PEG conjugate containing a hydrophobic DMG lipid anchor and hydrophilic 2K PEG spacer, while its terminal maleimide supports thiol-selective conjugation, ligand attachment, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DMG-PEG-Mal combines a hydrophobic lipid anchor with a hydrophilic PEG chain.
- PEG MW 2K: The 2K PEG spacer provides hydrophilic character and separates the reactive maleimide from the lipid anchor.
- DMG Lipid Anchor: Dimyristoyl glycerol specifically provides two saturated C14 lipid chains that support incorporation into lipid-based assemblies.
- Maleimide Functionality: The terminal maleimide provides a reactive site for conjugation with sulfhydryl-containing molecules.
- Thiol-Reactive Chemistry: Maleimide reacts efficiently with thiol groups under suitable conditions.
- Stable Conjugation: Maleimide-thiol coupling forms a stable thioether linkage specifically for functional conjugate development.
- PEG Spacer: The PEG chain provides spatial separation between the DMG lipid anchor and reactive maleimide group.
- Functional Lipid Platform: DMG, PEG, and maleimide functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Thiol Conjugation: DMG-PEG-Mal, MW 2K supports conjugation with thiol- and cysteine-containing molecules.
- Bioconjugation: The terminal maleimide enables attachment of compatible peptides, proteins, ligands, and other thiolated molecules.
- Lipid Nanoparticle Research: Supports introduction of thiol-reactive PEG functionality into lipid-based nanoparticle systems.
- Liposome Research: Enables functionalization of liposomes and other lipid assemblies.
- Ligand Conjugation: Supports attachment of thiol-containing ligands through maleimide-thiol chemistry.
- Nanoparticle Functionalization: Provides a reactive maleimide group for modifying compatible nanoparticle systems.
- Surface Modification: Supports thiol-reactive PEG presentation on compatible lipid and material surfaces.
- Biomaterial Research: Enables development of maleimide-functionalized lipid-PEG materials and conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis. Allow the material to reach room temperature before opening.
DMG-PEG-Mal, MW 2K combines a hydrophobic DMG lipid anchor, hydrophilic PEG spacer, and thiol-reactive maleimide group that specifically supports bioconjugation, ligand attachment, lipid nanoparticle modification, liposome functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.