DMG-PEG-Amine, MW 2K is an amine-functionalized lipid-PEG conjugate containing a hydrophobic DMG lipid anchor and hydrophilic 2K PEG spacer, while its terminal primary amine (-NH₂) supports bioconjugation, ligand attachment, lipid nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DMG-PEG-Amine combines a hydrophobic lipid anchor with a hydrophilic PEG chain.
- PEG MW 2K: The 2K PEG spacer provides hydrophilic character and separates the terminal amine from the lipid anchor.
- DMG Lipid Anchor: Dimyristoyl glycerol provides two saturated C14 lipid chains that specifically support incorporation into lipid-based assemblies.
- Primary Amine Functionality: The terminal primary amine (-NH₂) provides a reactive site for conjugation and further chemical modification.
- Amine-Reactive Coupling: The primary amine reacts with NHS esters, activated carboxyl groups, and other compatible amine-reactive functionalities.
- Stable Amide Formation: Coupling with activated carboxyl groups can form stable amide linkages for functional conjugate development.
- PEG Spacer: The PEG chain provides spatial separation between the DMG lipid anchor and terminal primary amine.
- Functional Lipid Platform: DMG, PEG, and amine functionality provide an especially versatile platform for lipid and nanomaterial modification.
Applications
- Bioconjugation: DMG-PEG-Amine, MW 2K supports conjugation with compatible amine-reactive molecules.
- Ligand Conjugation: The terminal amine supports attachment of activated ligands, peptides, proteins, and other functional molecules.
- Lipid Nanoparticle Research: Supports introduction of PEG and amine functionality into lipid-based nanoparticle systems.
- Liposome Research: Supports functionalization and formulation of liposomes and other lipid assemblies.
- Nanoparticle Functionalization: Provides a terminal primary amine for modification of compatible nanoparticle systems.
- Surface Modification: Supports amine-functional PEG presentation on compatible lipid and material surfaces.
- Drug Delivery Research: Provides a functional lipid-PEG component for experimental delivery-system development.
- Biomaterial Research: Supports development of amine-functionalized lipid-PEG materials and conjugation platforms.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DMG-PEG-Amine, MW 2K combines a hydrophobic DMG lipid anchor, hydrophilic PEG spacer, and reactive terminal primary amine and specifically provides a versatile functional lipid for conjugation, lipid formulation, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.