DMG-PEG 2000
Full Name: 1,2-Dimyristoyl-rac-glycerol-3-methoxypolyethylene glycol 2000
Abbreviation: DMG-PEG2000
Key Properties
- A PEGylated lipid composed of a dimyristoylglycerol (DMG) hydrophobic domain and a PEG 2000 hydrophilic chain.
- Non-ionizable, neutral amphiphilic lipid with high stability in aqueous formulations.
- Forms a protective hydrophilic layer on the surface of lipid nanoparticles (LNPs) to prevent aggregation and reduce nonspecific protein adsorption.
- Low toxicity, good biocompatibility, and high biodegradability.
- Soluble in chloroform, methanol, ethanol, and DMSO; readily incorporated into LNP lipid mixtures.
- Typically a white to off-white solid or waxy powder.
- Storage: −20 °C, desiccated and protected from light and oxidation.
Applications
- Widely used as a PEGylated helper lipid in mRNA vaccine and nucleic acid lipid nanoparticle (LNP) formulations.
- Stabilizes LNPs during formulation, storage, and in vivo circulation.
- Reduces immune recognition and opsonization, prolonging the blood circulation time of nanoparticles.
- Improves colloidal stability and prevents particle aggregation during manufacturing and administration.
- Key component in modern LNP systems for delivery of mRNA, siRNA, DNA, and gene-editing therapeutics.
- Used in liposomal and lipid-based drug delivery systems to enhance biocompatibility and circulation half-life.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
