Dde-Biotin-PEG4-azide
This product is a multifunctional PEG linker containing a Dde-protected biotin, a PEG4 spacer, and a terminal azide group. It specifically enables orthogonal deprotection, strong streptavidin binding, and click chemistry with alkynes for advanced bioconjugation.
Key Features and Benefits
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Dde-Protected Biotin: Allows selective, orthogonal deprotection when needed.
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Azide Group: Reacts with alkynes via CuAAC or SPAAC click chemistry.
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PEG4 Spacer: Improves solubility and reduces steric hindrance.
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Dual Reactivity: Combines affinity capture with click functionality.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links azide-modified molecules with biotin-binding systems.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with orthogonal handles.
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Material Science: Functionalizes polymers and nanoparticles with affinity and click groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates orthogonal Dde-protected biotin with azide click chemistry in a PEG4 scaffold, specifically offering flexibility for staged conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
