DBCO-Sulfo-NHS Ester (CAS 1400191-52-7) is a water-soluble reagent used primarily in bioconjugation and Click Chemistry. It contains an NHS ester group that reacts efficiently with primary amines, such as those on proteins or antibodies, forming stable covalent bonds. This makes it highly effective for modifying biomolecules in aqueous conditions without the need for organic solvents.
Key Features:
- Water-Soluble: Works in 100% aqueous buffers, avoiding the use of organic co-solvents, making it ideal for biological applications.
- Efficient Labeling: Reacts with primary amines (e.g., lysine residues), commonly used for modifying proteins, antibodies, and other macromolecules.
- Click Chemistry: The DBCO group enables copper-free Click Chemistry, reacting with azide-functionalized biomolecules to create stable triazole linkages.
- High Purity: Available at ≥95% purity, ensuring reliable results in experiments.
Applications:
- Protein Labeling: Used to modify proteins and antibodies through Azide-DBCO Reaction.
- Antibody-Drug Conjugates (ADCs): Ideal for the development of ADCs, where it links therapeutic agents to antibodies.
- Surface Modification: Used to functionalize aminosilane-coated surfaces for various assays and applications.
Stored at -20°C, this reagent offers high versatility for biological and chemical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
