DBCO-PEG8-acid
This product is a bifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG8 spacer, and a terminal carboxylic acid. It specifically enables copper-free click chemistry with azides and provides carboxyl functionality for amide coupling in bioconjugation and material science.
Key Features and Benefits
-
DBCO Group: Performs strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
-
PEG8 Spacer: Enhances solubility and reduces steric hindrance.
-
Carboxylic Acid: Couples efficiently with amines for stable amide bonds.
-
Dual Reactivity: Combines bioorthogonal click chemistry with carboxyl conjugation.
-
High Purity: Supports reproducible results in sensitive workflows.
Applications
-
Bioconjugation: Links azide-modified and amine-containing biomolecules.
-
Probe Development: Builds multifunctional probes with click and amide handles.
-
Drug Delivery: Provides PEGylated scaffolds for targeted delivery systems.
-
Material Science: Functionalizes polymers and nanostructures with dual chemistries.
Storage and Handling
-
Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product integrates copper-free click reactivity with amide coupling chemistry in a PEG8 scaffold, specifically offering a versatile linker for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
