DBCO-PEG12-acid
This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group for copper-free SPAAC click chemistry and a terminal carboxylic acid for amide coupling. The PEG12 spacer offers long-chain solubility, flexibility, and spacing, making it especially effective for bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
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DBCO Group: Enables rapid, catalyst-free click chemistry with azides.
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Carboxylic Acid: Couples efficiently with amines for stable amide bonds.
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PEG12 Spacer: Enhances solubility, hydrophilicity, and steric accessibility.
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Dual Reactivity: Supports orthogonal click and amide conjugation.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Couples biomolecules through SPAAC click and amide chemistry.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds for therapeutic conjugates.
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Material Science: Functionalizes polymers, surfaces, and nanoparticles.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged moisture exposure.
This product integrates copper-free click reactivity with amine-conjugatable acid chemistry in a PEG12 scaffold, specifically offering versatility for advanced conjugation and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
