DBCO-NH-PEG5-NHS ester
This product is a heterobifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG5 spacer, and an NHS ester. It specifically enables copper-free click chemistry and amine conjugation, offering solubility, medium spacing, and dual reactivity.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via SPAAC copper-free click chemistry.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG5 Spacer: Provides solubility, flexibility, and reduced steric hindrance.
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Dual Reactivity: Combines copper-free click chemistry with amine coupling.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links azide-modified and amine-containing biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with orthogonal handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click chemistry with amine coupling in a PEG5 scaffold, specifically offering solubility, flexibility, and multifunctionality.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
