DBCO-C4-PEG2-amine
This product is a heterobifunctional PEG linker containing a dibenzocyclooctyne (DBCO), a C4-PEG2 spacer, and a terminal amine. It specifically enables copper-free click chemistry and amide coupling, offering solubility, flexibility, and multifunctionality.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via SPAAC copper-free click chemistry.
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Primary Amine: Couples efficiently with carboxyls, NHS esters, or activated linkers.
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C4-PEG2 Spacer: Provides balanced hydrophilicity, solubility, and moderate flexibility.
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Dual Reactivity: Combines click chemistry with amide coupling functionality.
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High Purity: Ensures reproducibility in bioconjugation workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with dual orthogonal reactivity.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with click and amine groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click chemistry with amine coupling in a C4-PEG2 scaffold, specifically offering solubility, versatility, and multifunctional reactivity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
