DBCO-C4-amine TFA salt
DBCO-C4-amine TFA salt is a high-purity heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) moiety for rapid, catalyst-free strain-promoted azide–alkyne cycloaddition (SPAAC) click chemistry, and a terminal primary amine for versatile conjugation with activated esters (e.g., NHS esters) or other electrophiles. The C4 alkyl spacer provides optimal flexibility while maintaining hydrophobic character, enabling especially efficient coupling in both aqueous and organic systems.
Key Features
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DBCO group enables copper-free click chemistry with azides under mild conditions
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Primary amine allows coupling with NHS esters, isothiocyanates, and other activated carboxylic acids
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C4 spacer offers balanced flexibility and reactivity
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High chemical purity and stability
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Copper-free reaction avoids cytotoxicity and is biocompatible
Applications
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Site-specific labeling of biomolecules without metal catalysts
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Antibody–drug conjugate (ADC) development
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Nanoparticle and surface functionalization
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Preparation of multifunctional probes and imaging agents
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Biorthogonal click chemistry in live-cell or in vivo systems
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Bring to room temperature before opening
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Avoid repeated freeze–thaw cycles
This product features a DBCO group for copper-free click chemistry and a primary amine for broad conjugation, linked by a C4 spacer specifically for balanced reactivity and flexibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
