DBCO-C3-PEG4-amine
This product is a bifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG4 spacer with a C3 extension, and a terminal primary amine. It specifically enables copper-free click chemistry with azides and provides an accessible amine for further conjugation.
Key Features and Benefits
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DBCO Group: Performs strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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PEG4-C3 Spacer: Improves solubility and provides flexible spacing.
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Primary Amine: Couples with activated esters or carboxyl groups for stable amide bonds.
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Dual Reactivity: Combines bioorthogonal click chemistry with amine coupling.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes with click and amide handles.
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Drug Delivery: Constructs PEGylated scaffolds with dual functionality.
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Material Science: Functionalizes polymers and nanostructures with DBCO and amine groups.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to maintain reactivity.
This product integrates DBCO click chemistry with a terminal primary amine in a PEG4-C3 scaffold, specifically providing a versatile linker for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
