DADPS Biotin Azide
This product is a cleavable biotinylation reagent containing a DADPS linker, a biotin moiety, and a terminal azide. It specifically enables affinity enrichment, controlled release, and click chemistry, offering solubility and multifunctionality for proteomics and chemical biology.
Key Features and Benefits
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Biotin Moiety: Provides strong streptavidin and avidin binding for enrichment.
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Azide Group: Reacts with alkynes via CuAAC or SPAAC click chemistry.
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DADPS Linker: Cleaves under mild acidic conditions for controlled release.
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PEG-Like Spacer: Improves solubility and reduces steric hindrance.
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High Purity: Ensures reproducibility in sensitive enrichment workflows.
Applications
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Proteomics: Enables enrichment and release of biotinylated proteins or peptides.
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Bioconjugation: Links biomolecules with azide click chemistry.
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Probe Development: Builds cleavable affinity probes for imaging and diagnostics.
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Chemical Biology: Supports interactome mapping and target identification.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMSO; avoid premature hydrolysis or cleavage.
This product integrates biotin affinity, azide click reactivity, and a cleavable DADPS linker, specifically enabling efficient enrichment and controlled release strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
