Name: β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine
SKU: AP10901
Availability: InStock

β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine

$298.00 – $580.00

β-D-triacetylglucopyranosiduronyl Methyl Ester-Phenol-β-Alanine (CAS: 894096-02-7)

This β-glucuronic acid-based linker ensures controlled drug release through β-glucuronidase cleavage, enhancing the stability and targeted delivery of antibody-drug conjugates (ADCs) and other therapeutic payloads.

Unit

Price

Quantity

100 mg

$298

250 mg

$580

Would you like to inquire about bulk pricing?

β-D-triacetylglucopyranosiduronyl Methyl Ester-Phenol-β-Alanine (CAS: 894096-02-7)

This β-glucuronic acid-based linker enhances the stability and efficiency of antibody-drug conjugates (ADCs). It releases the drug through β-glucuronidase cleavage in the lysosome, ensuring controlled and targeted drug delivery.

Key Features:

Controlled Release: Breaks the β-glucuronide bond at the target site for precise drug release.
Enhanced Stability: Protects conjugates from degradation, improving half-life and bioavailability.
Targeted Delivery: Ensures drugs are released at the target site, improving effectiveness and reducing side effects.
Water-Soluble: Ensures stability and effectiveness for drug delivery.

β-glucuronide Phenol-β-Alanine Applications:

ADCs: Links cytotoxic drugs to antibodies for targeted therapy.
Peptide and Protein Conjugates: Enables efficient drug delivery.
Oligonucleotide Conjugates: Delivers therapeutic payloads using oligonucleotides.
Drug Delivery Research: Supports controlled release systems for targeted therapy.

AxisPharm offers glucuronide linkers and custom synthesis services to optimize ADC research and drug delivery.

Ref.

Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, et al. (May 2017). “Glucuronidation: driving factors and their impact on glucuronide disposition”. Drug Metabolism Reviews. 49 (2): 105–138.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.

β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine

Catalog #:	AP10901
Name:	β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine
Chemical Formula:	C₃₈H₄₀N₂O₁₄
Molecular Weight:	748.73
CAS:	894096-02-7
Purity:	≥95%
Availability:	In Stock
SDS:	Download

Unit	Price	Quantity
100 mg	$298	β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine quantity
250 mg	$580	β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine quantity

SKU: AP10901 Category: β-Glucuronide Linkers Tag: hot

Description
Synonyms
Shipping & Delivery

Description

Synonyms

Me-triacetyl-beta-D-glucopyranuronate-Ph-CH2OH-Fmoc
Me-triacetyl-|A-D-glucopyranuronate-Ph-CH2OH-Fmoc
(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9-yl)methoxy)carbonyl-amino) propanamido)-4-(hydroxymethyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate
(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonyl-amino)propanamido)-4-(hydroxymethyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate
(2S,3S,4S,5R,6S)-methyl-6-(2-(3-(((9H-fluoren-9yl)methoxy)carbonylamino) propanamido)-4-(hydroxymethyl)phenoxy)-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate

Shipping & Delivery

Ships within: 24 hours
Storage condition: -20 ° C
Shipping: Ambient Temperature