Boc-Val-Ala-PAB-OH
This product is a cleavable linker containing a Boc-protected amine, a Val–Ala dipeptide sequence for protease sensitivity, and a para-aminobenzyl self-immolative spacer. This design supports orthogonal synthesis and controlled payload release, making it especially valuable for ADC development, drug delivery, and probe design.
Key Features and Benefits:
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Boc Group: Acid-labile protection ensures controlled, stepwise synthesis.
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Val–Ala Dipeptide: Cleaved by proteases such as cathepsin B.
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PAB Spacer: Self-immolative unit ensures complete drug or probe release.
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Orthogonal Design: Supports multi-step conjugation strategies.
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High Purity: Ensures reproducibility in advanced research workflows.
Applications:
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ADC Development: Core cleavable linker for antibody–drug conjugates.
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Drug Delivery: Enables protease-triggered, site-specific payload release.
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Probe Development: Builds imaging and diagnostic tools with cleavable features.
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Bioconjugation: Supports orthogonal synthesis in multi-functional constructs.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature deprotection.
This product integrates Boc protection with a protease-sensitive Val–Ala dipeptide and a PAB spacer, making it an especially reliable building block for ADCs and targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
