Bis-sulfone-PEG4-methyl-tetrazine (CAS: 1854034-71-1) is a reagent designed for bioconjugation, commonly used in targeted drug development and molecular imaging. It includes a bis-sulfone for cysteine binding, a PEG4 spacer for better solubility, and a methyl-tetrazine group for fast, selective click chemistry.
Key Features:
- Bis-Sulfone Group: Enables specific binding to cysteine residues and forms stable thio bridges, enhancing protein modification.
- PEG4 Spacer: Increases solubility and reduces bulkiness, making it ideal for complex conjugations.
- Methyl-Tetrazine: Allows rapid, bioorthogonal reactions with TCO compounds through click chemistry.
Applications:
- Targeted Protein Labeling: Labels proteins at cysteine sites, useful for research and therapeutic applications.
- Antibody-Drug Conjugates (ADCs): Applied in ADC development for precise cancer treatment.
- Click Chemistry: Supports bioorthogonal labeling for bioconjugation and molecular imaging.
Storage and Handling:
- Storage: Store at -20°C in a dry, dark environment.
- Handling: Use in an inert atmosphere to ensure stability.
Bis-sulfone-PEG-methyl-tetrazine is a reliable tool for bioconjugation, enabling precise cysteine targeting, stable thio bridge formation, and selective click reactions, essential in developing targeted therapies and molecular probes.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
