Biotin-Poly(ε-caprolactone) (PCL-biotin), MW 2K is a biotin-functionalized poly(ε-caprolactone) with a molecular weight of approximately 2K. It combines a low-molecular-weight, biodegradable PCL backbone with terminal biotin functionality specifically for avidin-biotin binding, bioconjugation, nanoparticle functionalization, surface modification, affinity-based assembly, and biomaterial research.
Key Features and Benefits
- Biotin-Functionalized PCL: Combines biodegradable poly(ε-caprolactone) with terminal biotin functionality for affinity-based binding and material functionalization.
- MW 2K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and biomaterial research.
- Biotin Functionality: The terminal biotin group provides a high-affinity recognition site for avidin, streptavidin, and related biotin-binding proteins.
- Biodegradable Polyester: The PCL backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Semicrystalline PCL Backbone: The PCL structure supports semicrystalline polymer formation and also provides useful material-forming properties for biodegradable polymer research.
- Good Processability: The low molecular weight facilitates polymer dissolution, formulation, and functionalization compared with higher-molecular-weight PCL grades.
- Affinity-Based Conjugation: Biotin functionality enables strong noncovalent association with avidin or streptavidin for modular assembly and functionalization.
Applications
- Avidin-Biotin Binding: Supports high-affinity interaction with avidin, streptavidin, and related biotin-binding proteins.
- Bioconjugation: Enables affinity-based assembly with appropriately designed avidin- or streptavidin-containing biomolecular systems.
- Nanoparticle Functionalization: Supports preparation and functionalization of biodegradable PCL nanoparticles and related delivery systems.
- Surface Modification: Enables incorporation of biotin functionality into PCL-containing surfaces, coatings, and materials.
- Affinity Capture: Supports development of biotin-avidin or biotin-streptavidin systems for affinity-based capture and immobilization research.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Polymer Functionalization: Enables incorporation of biotin recognition into PCL-based polymer architectures and functional materials.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
Biotin-Poly(ε-caprolactone) (PCL-biotin), MW 2K provides a low-molecular-weight biodegradable PCL platform with terminal biotin functionality and good processability and specifically supports avidin-biotin binding, bioconjugation, nanoparticle functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
