Amino-PEG20-acid
Amino-PEG20-acid is a high-purity heterobifunctional PEG linker featuring a terminal primary amine and a carboxylic acid group, connected by a PEG20 spacer. The amine group allows conjugation to activated esters or aldehydes, while the carboxylic acid can be coupled to amines via amide bond formation. The PEG20 chain imparts high hydrophilicity, extended spacing, and flexibility, specifically enabling use in both aqueous and organic systems for bioconjugation and material modification.
Key Features
-
Heterobifunctional PEG linker with amine and carboxylic acid termini
-
Amine group reacts with activated esters, aldehydes, and isothiocyanates
-
Carboxylic acid enables amide coupling to amines
-
PEG20 spacer provides hydrophilicity, flexibility, and reduced steric hindrance
-
High chemical purity for consistent results
Applications
-
Protein and peptide conjugation
-
Antibody–drug conjugate (ADC) synthesis
-
Surface and nanoparticle modification
-
Polymer–drug or polymer–biomolecule conjugates
Storage and Handling
-
Store at –20 °C, protected from light and moisture
-
Warm to room temperature before opening
-
Avoid repeated freeze–thaw cycles
This product combines a reactive amine and a carboxylic acid on opposite ends of a PEG20 chain, offering especially high solubility and versatile conjugation options in bioconjugation and material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
