Amino-PEG1-acid(NH2-PEG-COOH) is a PEG derivative containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer can increase solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.