Acid-CH2-PEG3-CH2-t-butyl Ester
This product is a high-purity, monodisperse PEG linker featuring a free carboxylic acid on one end and a t-butyl ester-protected acid on the other. The PEG3 spacer specifically enhances hydrophilicity, reduces steric hindrance, and provides optimal spacing between functional groups, enabling efficient conjugation in both aqueous and organic environments. The t-butyl ester acts as an acid-labile protecting group, allowing selective deprotection for stepwise functionalization.
Key Features and Benefits:
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Dual Carboxylic Acid Functionality: One free acid for immediate conjugation; one t-butyl ester-protected acid for controlled activation.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive sites.
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High Purity: Ensures reliable and reproducible coupling performance.
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Orthogonal Protection: Facilitates multi-step conjugation strategies without cross-reactivity.
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Versatile Use: Suitable for drug delivery systems, bioconjugation, and surface functionalization.
Applications:
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Stepwise Bioconjugation: Functionalize biomolecules or polymers with controlled sequence.
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Drug Delivery: Prepare linkers for targeted delivery systems.
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Surface Modification: Introduce carboxyl groups to nanoparticles, hydrogels, or sensor surfaces.
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Polymer Chemistry: Enable functional diversity in PEGylated materials.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to prevent premature hydrolysis; avoid strong acids or bases until deprotection is intended.
This product offers dual acid functionality with orthogonal protection, making it an especially valuable reagent for controlled conjugation in research, biopharmaceutical development, and advanced materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
