2-(3-Methyl-3H-diazirin-3-yl)ethan-1-amine
This product is a photoactivatable crosslinking reagent featuring a diazirine group and a terminal primary amine. The diazirine generates reactive carbenes under UV light, enabling covalent protein labeling, while the amine provides versatile coupling for bioconjugation and probe design.
Key Features and Benefits:
-
Diazirine Group: Generates reactive carbenes upon UV activation for covalent crosslinking.
-
Primary Amine: Couples with carboxyls, NHS esters, or other electrophiles.
-
Compact Design: Provides minimal steric hindrance for efficient labeling.
-
High Reactivity: Enables stable, light-induced covalent modification.
-
High Purity: Ensures reproducibility in crosslinking experiments.
Applications:
-
Protein Labeling: Facilitates covalent capture of transient or weak interactions.
-
Photoaffinity Probes: Builds light-activated probes for target identification.
-
Bioconjugation: Combines photoreactive labeling with amine chemistry.
-
Chemical Biology: Useful for studying biomolecular interactions in living systems.
Storage and Handling:
-
Storage: Store at –20 °C in a light-protected container.
-
Handling: Avoid direct light exposure; use anhydrous solvents (e.g., DMSO, DMF).
This product provides dual functionality for UV-triggered crosslinking and amine conjugation, making it an essential tool specifically in photoaffinity labeling and chemical biology.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.