2-(3-But-3-ynyl-3H-Diazirin-3-yl)-ethanol

2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol

This product is a photoactivatable linker containing a diazirine group for UV-triggered carbene crosslinking and a terminal alkyne for click chemistry. The hydroxyl handle improves solubility and enables further functionalization, making it especially effective for photoaffinity labeling and multifunctional probe design.

Key Features and Benefits:

• Diazirine Group: Generates reactive carbenes upon UV exposure for covalent labeling.

• Alkyne Handle: Supports CuAAC and SPAAC click chemistry with azides.

• Hydroxyl Group: Provides solubility and modification opportunities.

• Compact Structure: Minimizes steric hindrance for efficient labeling.

• High Purity: Ensures reproducibility in photoaffinity experiments.

Applications:

• Photoaffinity Labeling: Captures transient and weak biomolecular interactions.

• Bioconjugation: Combines photoreactive crosslinking with orthogonal alkyne chemistry.

• Probe Development: Builds multifunctional probes for chemical biology.

• Drug Discovery: Facilitates target identification and validation.

Storage and Handling:

• Storage: Store at –20 °C in a light-protected container.

• Handling: Avoid UV exposure before use; handle in anhydrous solvents (e.g., DMF, DMSO).

This product provides UV-activated crosslinking with a click-ready alkyne, making it an especially versatile tool for probe synthesis, protein labeling, and chemical biology research.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.