2-(3-Methyl-3H-diazirin-3-yl)ethan-1-amine

2-(3-Methyl-3H-diazirin-3-yl)ethan-1-amine

This product is a photoactivatable crosslinking reagent featuring a diazirine group and a terminal primary amine. The diazirine generates reactive carbenes under UV light, enabling covalent protein labeling, while the amine provides versatile coupling for bioconjugation and probe design.

Key Features and Benefits:

• Diazirine Group: Generates reactive carbenes upon UV activation for covalent crosslinking.

• Primary Amine: Couples with carboxyls, NHS esters, or other electrophiles.

• Compact Design: Provides minimal steric hindrance for efficient labeling.

• High Reactivity: Enables stable, light-induced covalent modification.

• High Purity: Ensures reproducibility in crosslinking experiments.

Applications:

• Protein Labeling: Facilitates covalent capture of transient or weak interactions.

• Photoaffinity Probes: Builds light-activated probes for target identification.

• Bioconjugation: Combines photoreactive labeling with amine chemistry.

• Chemical Biology: Useful for studying biomolecular interactions in living systems.

Storage and Handling:

• Storage: Store at –20 °C in a light-protected container.

• Handling: Avoid direct light exposure; use anhydrous solvents (e.g., DMSO, DMF).

This product provides dual functionality for UV-triggered crosslinking and amine conjugation, making it an essential tool specifically in photoaffinity labeling and chemical biology.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.