β-Lapachone is a natural ortho‑naphthoquinone isolated from Tabebuia avellanedae. It exerts potent anticancer activity via NQO1‑mediated futile redox cycling, generating ROS, inducing DNA damage, PARP‑1 hyperactivation, and NAD⁺/ATP depletion, leading to selective death of NQO1‑overexpressing tumor cells. It also shows anti‑inflammatory, antimicrobial, and neuroprotective effects.
Key Features and Benefits
- Naphthoquinone Compound: β-Lapachone is a bioactive ortho-naphthoquinone originally associated with lapacho tree-derived compounds.
- NQO1-Activated: β-Lapachone can undergo NQO1-mediated reduction and redox cycling in cells with sufficient NQO1 activity.
- ROS Generation: NQO1-dependent redox cycling can produce reactive oxygen species and oxidative stress.
- DNA Damage Research: Oxidative stress associated with β-lapachone can produce DNA damage and activate cellular repair pathways.
- Cell Death Studies: Widely investigated for mechanisms specifically linking NQO1 activity, oxidative stress, DNA damage, and cell death.
- Research Tool: Useful for studying redox biology, NQO1-dependent pharmacology, and cancer cell metabolism.
Applications
- Cancer Research: Used to investigate selective responses of NQO1-expressing cancer cells.
- NQO1 Research: Supports studies of NAD(P)H:quinone oxidoreductase 1 activity and related pathways.
- Oxidative Stress Research: Used to investigate ROS production and cellular responses to oxidative stress.
- DNA Damage Research: Supports studies specifically involving oxidative DNA damage and DNA repair responses.
- Cell Signaling: Used to investigate downstream pathways associated with redox stress and cellular metabolism.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container. Protect from light, moisture, and excessive heat.
- Handling: Use appropriate laboratory practices and minimize unnecessary exposure to light and environmental moisture.
β‑Lapachone is a useful research compound for studying NQO1-dependent redox cycling and oxidative stress that also supports research into DNA damage, cellular metabolism, cancer biology, and cell-death mechanisms.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
