Fluorescent PEG: Enhancing Pharmaceutical Research with Advanced Polymer Technology
Fluorescent PEG, or fluorescent polyethylene glycol, represents an innovative class of polymers widely recognized for its unique fluorescent properties and excellent biocompatibility. This specialized polymer is making a significant impact in pharmaceutical research and development, particularly in drug delivery, biosensing, and molecular imaging.
Extravasation of the fluorescent macromolecule IRDye 800CW-PEG to the brain after treatment with (left) ACT+A+E and (right) ACT+A.
Key Features and Benefits:
- Fluorescent Properties: Fluorescent PEG is engineered with fluorescent dyes attached to the polymer backbone. This modification allows researchers to visualize PEG molecules and track their movement within biological systems with high precision.
- Enhanced Drug Delivery: The incorporation of PEG improves the solubility and stability of drugs, making it an ideal choice for drug delivery systems. This enhancement ensures that drugs remain effective and stable, leading to better therapeutic outcomes.
- Biocompatibility: PEG is a non-toxic and non-immunogenic polymer. It is not recognized by the immune system, reducing the risk of adverse reactions. This makes PEG an excellent candidate for various medical applications, especially in drug delivery systems.
- Superior Properties: Fluorescent PEG outperforms conventional fluorescent molecules due to its improved hydrophilicity. Fluorescent probes such as Cyanine 3, Cyanine 5, Cyanine 7, Fluorescein, BDP, Rhodamine, and Pyrene, with emission ranges from UV to near-infrared, offer superior brightness, high photo stability, and resistance to self-quenching.
Applications:
- Drug Delivery Systems: Enhances solubility and stability, facilitating effective and controlled drug delivery.
- Biosensors: Improves detection sensitivity and accuracy in biosensing applications.
- Molecular Imaging: Enables detailed imaging and tracking of biological processes through advanced fluorescent properties.
Fluorescent PEG is revolutionizing pharmaceutical research by providing advanced solutions for drug delivery, imaging, and sensing. For more information or to explore our range of fluorescent PEG products, please contact us or browse our product offerings.
Ref:
Okuda T, Kobayashi Y, Yanamoto S, Okamoto H. PEG conjugation of a near-infrared fluorescent probe for noninvasive dual imaging of lung deposition and gene expression by pulmonary gene delivery. J Drug Target. 2012 Nov;20(9):801-12.
Reiber, T., Hübner, O., Dose, C. et al. Fluorophore multimerization on a PEG backbone as a concept for signal amplification and lifetime modulation. Sci Rep 14, 11882 (2024).
Aslund, Andreas & Snipstad, Sofie & Healey, Andrew & Kvåle, Svein & Torp, Sverre & Sontum, Per & Davies, Catharina & van Wamel, Annemieke. (2017). Efficient Enhancement of Blood-Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT). Theranostics. 7. 23-30.
