AmdU (5-azidomethyl-2′-deoxyuridine) is a nucleoside that contains an azide group. The structure of the nucleoside is similar to thymidine, and it is incorporated into nascent DNA by cellular polymerases, similarly to EdU.Unlike EdU that needs to be further modified with azides in the presence of copper catalyst, AmdU can also react in the absence of copper catalyst using spAAC Click Chemistry with strained cycloalkynes, such as cyclooctynes. This enables detection of nascent DNA in benign, copper free conditions.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.