PEGylation is the process of attaching polymer PEG chains to molecules (most commonly peptides, proteins and antibody fragments), which can improve the safety and efficiency of many therapeutic agents. It will change its physical and chemical properties, including changes in conformation, electrostatic binding, and hydrophobicity. These physical and chemical changes increase the systemic retention of the therapeutic agent. Moreover, it can affect the binding affinity of the therapeutic part to cell receptors, and can change the absorption and distribution patterns.
Axispharm PEG linker (PEGylation reagent) can be called several important pharmacological advantages by increasing the molecular weight of the molecule and the unmodified form. For example, the solubility of the drug is improved, the frequency is reduced, the toxicity is reduced, the cycle life is extended, and the drug is stable. Improved performance and enhanced protection against protein degradation.
Axispharm provides a small number of PEG linkers-maleated reduction, pulverized disulfide, amine, carboxylic acid and NHS ester functionalized PEG, such as nh2-peg-nh2, mPEG-NH2, which can be linked to proteins. Typical reactive amino acids include Lysine, cysteine, histidine, arginine, aspartic acid, glutamic acid, serine, threonine, tyrosine. As a result, Axispharm also provides customized PEG synthesis services to meet the different needs of customers for polycholesterolization.