PCL-PEG-Rhodamine B (PCL-PEG-RhB), MW x 5K, n 1K is a fluorescent amphiphilic block copolymer composed of poly(ε-caprolactone), polyethylene glycol, and a Rhodamine B fluorophore. The 5K PCL block provides a dominant hydrophobic domain for self-assembly and hydrophobic cargo incorporation, while the 1K PEG block provides surface functionality and the Rhodamine B label enables fluorescence-based tracking.
Key Features and Benefits
- Fluorescent Amphiphilic Copolymer: Integrates hydrophobic PCL, hydrophilic PEG, and a fluorescent Rhodamine B label.
- PCL MW 5K: Provides a biodegradable hydrophobic block for nanoparticle or micelle core formation and hydrophobic cargo incorporation.
- PEG MW 1K: Provides a short hydrophilic segment specifically for interfacial stabilization and surface hydration.
- PCL-Rich Architecture: The 5:1 PCL-to-PEG molecular weight ratio strongly favors hydrophobic domains and core-forming behavior.
- Rhodamine B Fluorescence: Provides a fluorescent signal useful for visualization and tracking of polymer-containing formulations.
- Carrier Tracking: Enables investigation of nanoparticle localization, cellular uptake, intracellular trafficking, and polymer distribution.
Applications
- Fluorescent Nanoparticles: Preparation of Rhodamine B-labeled polymeric nanoparticles, micelles, and related assemblies.
- Drug Delivery Research: Tracking of polymeric carriers containing hydrophobic drugs or other poorly water-soluble compounds.
- Cellular Uptake Studies: Fluorescence-based evaluation of polymer or nanoparticle internalization by cells.
- Biodistribution Research: Tracking of fluorescent polymer carriers in suitable experimental models.
- Biomaterial Imaging: Visualization of polymer localization and transport in biomaterial and tissue-engineering studies.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry, light-protected conditions.
- Handling: Protect from light, moisture, and excessive heat to preserve polymer integrity and fluorescence performance.
This product provides a strongly PCL-rich amphiphilic structure together with a fluorescent Rhodamine B label and is especially useful for preparing traceable hydrophobic polymeric carriers and studying nanoparticle uptake, localization, transport, and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.