PCL-PEG-Rhodamine B (PCL-PEG-RhB), MW x 4K, n 5K is a fluorescent amphiphilic block copolymer composed of poly(ε-caprolactone), polyethylene glycol, and a Rhodamine B fluorophore. The 4K PCL block provides a biodegradable hydrophobic domain for self-assembly and cargo incorporation, while the 5K PEG block promotes aqueous stabilization and the Rhodamine B label enables fluorescence-based tracking.
Key Features and Benefits
- Fluorescent Amphiphilic Copolymer: Integrates hydrophobic PCL, hydrophilic PEG, and a fluorescent Rhodamine B label.
- PCL MW 4K: Provides a biodegradable hydrophobic block for nanoparticle or micelle core formation and hydrophobic cargo incorporation.
- PEG MW 5K: Provides a longer hydrophilic segment specifically for aqueous compatibility, surface hydration, and steric stabilization.
- PEG-Rich Architecture: The 5:4 PEG-to-PCL molecular weight ratio favors hydrophilic surface stabilization while retaining amphiphilic self-assembly.
- Rhodamine B Fluorescence: Provides a fluorescent signal useful for visualization and tracking of polymer-containing formulations.
- Carrier Tracking: Enables investigation of nanoparticle localization, cellular uptake, intracellular trafficking, and polymer distribution.
Applications
- Fluorescent Nanoparticles: Preparation of Rhodamine B-labeled polymeric nanoparticles, micelles, and related assemblies.
- Drug Delivery Research: Fluorescence-based tracking of polymeric carriers and drug delivery systems.
- Cellular Uptake Studies: Evaluation of polymer or nanoparticle internalization using fluorescence-based methods.
- Biodistribution Research: Tracking of fluorescent polymer carriers in suitable experimental models.
- Biomaterial Imaging: Visualization of polymer localization and transport in biomaterial and tissue-engineering studies.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry, light-protected conditions.
- Handling: Protect from light, moisture, and excessive heat to preserve polymer integrity and fluorescence performance.
This product combines amphiphilic PCL-PEG architecture with Rhodamine B fluorescence and enhanced PEG-mediated surface stabilization and is especially useful for preparing traceable polymeric carriers and studying nanoparticle uptake, localization, transport, and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.