PCL-PEG-Rhodamine B (PCL-PEG-RhB), MW x 1K, n 2K is a fluorescent amphiphilic block copolymer composed of poly(ε-caprolactone), polyethylene glycol, and a Rhodamine B fluorophore. The 1K PCL block provides a short hydrophobic domain for polymer assembly, while the 2K PEG block promotes aqueous stabilization and the Rhodamine B label enables fluorescence-based tracking.
Key Features and Benefits
- Fluorescent Amphiphilic Copolymer: Integrates hydrophobic PCL, hydrophilic PEG, and a fluorescent Rhodamine B label.
- PCL MW 1K: Provides a short biodegradable hydrophobic segment for amphiphilic assembly and hydrophobic interactions.
- PEG MW 2K: Provides a hydrophilic segment for aqueous compatibility, surface hydration, and steric stabilization.
- PEG-Rich Architecture: The 2:1 PEG-to-PCL molecular weight ratio favors hydrophilic surface properties while retaining amphiphilic assembly behavior.
- Rhodamine B Fluorescence: Provides a fluorescent signal for visualization and tracking of polymer-containing formulations.
- Carrier Tracking: Enables investigation of nanoparticle localization, cellular uptake, intracellular trafficking, and polymer distribution.
Applications
- Fluorescent Nanoparticles: Preparation of Rhodamine B-labeled polymeric nanoparticles, micelles, and related assemblies.
- Drug Delivery Research: Enables fluorescence-based tracking of polymeric carriers and delivery systems.
- Cellular Uptake Studies: Supports fluorescence-based evaluation of polymer or nanoparticle internalization.
- Biodistribution Research: Enables tracking of fluorescent polymer carriers in suitable experimental models.
- Biomaterial Imaging: Supports visualization of polymer localization and transport in biomaterial and tissue-engineering studies.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry, light-protected conditions.
- Handling: Protect from light, moisture, and excessive heat to preserve polymer integrity and fluorescence performance.
This product combines a short PCL block with a PEG-rich architecture and Rhodamine B fluorescence and specifically hydrophilically stabilized, traceable polymer systems for nanoparticle imaging, cellular uptake, localization, and drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.