Poly(L-Arginine)-mPEG, MW X 5.8K, n 2K is a functional block copolymer composed of poly(L-arginine) (PArg) and methoxy polyethylene glycol (mPEG). This grade combines approximately 5.8K PArg with 2K mPEG, providing a PArg-rich architecture with guanidinium functionality and a hydrophilic PEG segment specifically for polymer functionalization, bioconjugation, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines cationic PArg with hydrophilic mPEG for polymer modification, conjugation, drug delivery, and biomaterial development.
- PArg MW 5.8K: Provides a poly(amino acid) segment with pendant guanidinium groups for ionic and molecular interactions.
- mPEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility, hydration, and interfacial stabilization.
- PArg-Rich Architecture: The approximately 2.9:1 PArg-to-mPEG molecular weight ratio favors cationic PArg content while retaining a hydrophilic mPEG component.
- Guanidinium-Rich Polymer: The PArg block provides positively charged guanidinium groups that support electrostatic interactions with negatively charged molecules and materials.
- Methoxy-Terminated PEG: Provides a nonreactive methoxy PEG terminus while the PArg block supplies the cationic functionality of the polymer.
- Functional Polymer Platform: Combines a cationic poly(L-arginine) segment with hydrophilic mPEG for development of functional polymer systems and biomaterials.
Applications
- Drug Delivery: Supports development of functional polymer systems and drug-delivery carriers.
- Ionic Complex Formation: Provides guanidinium-containing PArg segments for electrostatic interactions with negatively charged molecules, polymers, and biomaterials.
- Bioconjugation: Supports development of poly(L-arginine)-PEG conjugates and functional biomolecular systems.
- Polymer Functionalization: Provides a cationic poly(amino acid) block for incorporation into functional polymer systems.
- Nucleic Acid Delivery Research: Supports research involving electrostatic complexation with negatively charged nucleic acids and related delivery systems.
- Surface Modification: Supports development of cationic polymer coatings and modified biomaterial surfaces.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for coatings, conjugates, delivery systems, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines cationic PArg with hydrophilic mPEG in a PArg-rich block copolymer. It specifically supports drug delivery, ionic complex formation, bioconjugation, polymer functionalization, nucleic acid delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
