OPSS-Poly(L-Glutamic Acid), MW 2.5K is an OPSS-functionalized, carboxyl-rich poly(amino acid) based on poly(L-glutamic acid). It combines thiol-reactive OPSS functionality with a compact polyanionic polymer chain specifically for conjugation, functionalization, and biomaterial research.
Key Features and Benefits
- Poly(amino acid) Backbone: Poly(L-glutamic acid) provides a biodegradable polymer framework with multiple pendant carboxyl groups.
- MW 2.5K: The low molecular weight polymer specifically provides a compact poly(L-glutamic acid) chain with multiple carboxyl groups.
- Terminal OPSS Group: Provides orthopyridyl disulfide functionality specifically for selective reaction with compatible thiol-containing molecules.
- Thiol-Reactive Chemistry: OPSS reacts with sulfhydryl groups through disulfide exchange to form disulfide-linked conjugates.
- Disulfide Conjugation: The resulting disulfide linkage can undergo cleavage under suitable reducing conditions.
- Carboxyl-Rich Structure: Pendant carboxyl groups provide additional sites for chemical modification and conjugation.
- Polyanionic Character: Deprotonated carboxyl groups specifically provide negative charge under suitable pH conditions.
- Multifunctional Platform: Combines thiol-reactive OPSS chemistry with the carboxyl-rich properties of poly(L-glutamic acid).
Applications
- Thiol Conjugation: OPSS supports coupling with compatible thiol-containing molecules through disulfide exchange.
- Bioconjugation: Enables attachment of compatible thiol-containing peptides, proteins, ligands, and other biomolecules.
- Reversible Conjugation: Disulfide linkages provide a strategy for cleavable conjugates under suitable reducing conditions.
- Polymer Functionalization: Combines terminal OPSS reactivity with pendant carboxyl groups for additional polymer modification.
- Nanoparticle Functionalization: Supports thiol-mediated modification of compatible polymeric and nanoparticle systems.
- Surface Modification: Provides reactive functionality for developing modified surfaces and polymer coatings.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of functional polymers, conjugates, nanoparticles, surfaces, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
OPSS-Poly(L-Glutamic Acid), MW 2.5K combines a compact, carboxyl-rich poly(amino acid) chain with thiol-reactive OPSS functionality and specifically supports disulfide conjugation, polymer functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.