Poly(DL‑lactide) (PDLLA, MW 200‑300K) is ultra‑high‑molecular‑weight amorphous biodegradable aliphatic polyester synthesized via ring‑opening polymerization of racemic D,L‑lactide. Random distribution of D‑lactide and L‑lactide repeating units breaks molecular‑chain regularity and eliminates crystallinity, which is fundamentally different from semi‑crystalline PLLA homopolymer. This ultra‑high‑MW PDLLA exhibits exceptional mechanical strength, superior toughness and excellent film‑forming capacity, with extremely slow homogeneous hydrolytic degradation. Its fully amorphous matrix enables uniform water diffusion inside the polymer bulk, supporting continuous degradation and sustained drug release over more than one year. Degradation metabolite is endogenous lactic acid, which can be metabolized and eliminated in vivo with reliable biosafety. It is mainly used for high‑performance absorbable structural polymer prototypes, large‑size implant biomaterials and ultra‑long‑cycle tissue‑engineering research.
Key Features
- MW: 200000‑300000 Da, fully amorphous poly(DL‑lactide), no melting point; glass transition temperature Tg ≈55‑65 °C
- Amorphous microstructure ensures homogeneous water infiltration and uniform hydrolytic degradation, avoiding heterogeneous degradation triggered by crystalline domains
- Ultra‑high mechanical strength and toughness; suitable for hot‑press molding, solvent casting, electrospinning and other polymer processing operations
- Excellent biocompatibility; degradation product is endogenous lactic acid
- Soluble in DCM, CHCl₃, THF, DMF; insoluble in water, alcohols and aliphatic alkanes
- Extremely hygroscopic; ester bonds are highly susceptible to moisture‑induced hydrolysis; strict moisture‑proof handling and storage are mandatory
Applications
- Raw polymer for manufacturing ultra‑high‑strength large‑scale implant depots and bulky structural scaffolds for ultra‑long‑term drug‑delivery research
- Preparation of high‑toughness dense biodegradable films and electrospun membranes for multi‑year tissue‑engineering research
- Prepolymer feedstock for synthesis of ultra‑high‑molecular‑weight functional PDLLA derivatives
- Research‑grade raw material for developing high‑performance absorbable medical device prototypes
Handling & Storage
- Store at −20 °C under dry sealed condition; strictly moisture‑proof; avoid violent temperature‑humidity fluctuations
- Allow the whole container to fully equilibrate to room temperature before opening to prevent condensation‑water contamination
- Hermetically seal immediately after partial sampling; repeated freeze‑thaw cycles are strictly prohibited
- For research‑only use; not intended for direct clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.