Poly(DL‑lactide) (PDLLA, MW 500‑700K) is ultra‑high‑molecular‑weight amorphous biodegradable aliphatic polyester synthesized by ring‑opening polymerization of racemic D,L‑lactide. Randomly arranged D‑lactide and L‑lactide repeating units disrupt molecular‑chain regularity and completely eliminate crystallinity, which is fundamentally different from semi‑crystalline PLLA homopolymer. This top‑grade ultra‑high‑MW PDLLA delivers exceptional mechanical strength, supreme toughness and outstanding film‑forming performance, with extremely slow homogeneous hydrolytic degradation. Its fully‑amorphous matrix enables uniform water diffusion throughout polymer bulk, supporting continuous degradation and sustained drug release over multiple years. Degradation metabolite is endogenous lactic acid that can be metabolized and eliminated in vivo with reliable biosafety. It is mainly applied for high‑end heavy‑duty absorbable structural polymer prototypes, extra‑large‑size implant biomaterials and multi‑year ultra‑long‑cycle tissue‑engineering research.
Key Features
- MW: 500000‑700000 Da, fully amorphous poly(DL‑lactide), no melting point; glass transition temperature Tg ≈57‑67 °C
- Amorphous microstructure achieves homogeneous water infiltration and uniform hydrolytic degradation, avoiding heterogeneous degradation originating from crystalline domains
- Exceptional mechanical strength and toughness; suitable for hot‑press molding, solvent casting, electrospinning and other rigorous polymer‑processing techniques
- Excellent biocompatibility; degradation product is endogenous lactic acid
- Soluble in DCM, CHCl₃, THF, DMF; insoluble in water, alcohols and aliphatic alkanes
- Extremely hygroscopic; ester bonds are highly susceptible to moisture‑triggered hydrolysis; strict full‑process moisture‑proof handling is indispensable
Applications
- Raw polymer for manufacturing ultra‑high‑strength extra‑large‑volume heavy‑duty implant depots and bulky structural scaffolds for multi‑year ultra‑long‑term drug‑delivery research
- Feedstock for preparing high‑toughness dense biodegradable films and high‑performance electrospun membranes for multi‑year tissue‑engineering research
- Prepolymer feedstock for synthesis of ultra‑high‑molecular‑weight functional PDLLA derivatives
- Research‑grade raw material for developing high‑end heavy‑duty absorbable medical‑device prototypes
Handling & Storage
- Store at −20 °C under dry sealed condition; strictly moisture‑proof; prevent drastic temperature‑humidity fluctuations
- Fully equilibrate container to room temperature before opening package to avoid condensation‑water contamination
- Hermetically seal immediately after partial sampling; repeated freeze‑thaw cycles are strictly prohibited
- For research‑only use; not intended for direct clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.